We conduct cutting-edge cardiovascular research.
Computational fluid dynamic (CFD) simulation of the blood flow patterns in a normal carotid artery bifurcation. Movie kindly provided by Professor David Steinman (lab webiste: https://bsl.mie.utoronto.ca/)
The laboratory combines genomics approaches with unbiased functional screening and biochemical studies to identify the signaling pathways and transcriptional programs that regulate endothelial cell responses to flow. The goal is to identify molecules within these pathways that can be targeted to prevent or treat atherosclerosis.
The cross-disciplinary nature of our work has led to interactions with physicist and engineers as well as molecular and cellular biologists and clinical scientists.
Staining of RelA and VCAM-1 in the murine aorta
(Circ Res 2011;108:950-959).
Our research focuses on the biomechanical mechanisms that control atherosclerosis, a disease of arteries that can lead to angina, heart attack and stroke. Branches and bends of arteries are prone to atherosclerosis because complex patterns of blood flow at these sites generate frictional forces (shear stress) that trigger pathophysiological changes in endothelial cells.
TWIST1 expression is enriched at a low shear stress region of the aorta (Mahmoud et al. Circ Res. 2016 119: 450-462).
Model of integrin structural changes in response to mechanical force
(Xanthis et al J Cell Sci 2019;132;jcs229542).
Current Projects (current funding £1.7M).
BHF Programme Grant: “Role of the transcription factor TWIST1 in endothelial pathophysiology and atherosclerosis progression”. 2020-2025
BHF Project Grant: “Role of endothelial STAT5A in focal vascular inflammation and atherosclerosis”. 2018-2021
BHF Project Grant: “Role of c-Rel NF-kB subunits in endothelial pathophysiology and atherosclerosis”. 2018-2020
BHF Intermediate Basic Science Fellowship: “Role of the mechanoreceptor Pkd1 in endothelial dysfunction and atherosclerosis”. Awarded to Dr Jovana Serbanovic-Canic with Prof. Evans and Prof. Tim Chico supervisors.
BHF PhD Studentship: “c-REL transcriptional programmes driving atherosclerosis”. 2020-2023
NC3Rs/BHF PhD Studentship: “Using zebrafish embryos to identify genes that protect against atherosclerosis”. 2018-2021
A* Star Institute Singapore, PhD Scholarship: “The role of HIF2 in endothelial mechanobiology and atherosclerosis”. 2016-2020